![]() ![]() “This study provides a granular, cell-specific understanding of the stages of lung development and discovers that each cell type matures along a specific timeline,” said Jennifer Sucre, MD, the paper’s co-corresponding author with Jonathan Kropski, MD. ![]() 20 in the journal Development, is the longest and most detailed “developmental roadmap” of the lung achieved to date. Using a technique called single-cell RNA-sequencing, or scRNA-seq, the researchers followed more than 100,000 cells from embryonic day 12 to postnatal day 14 in the mouse. The result, reported Dec. To find out why, researchers at Vanderbilt University Medical Center have constructed a single-cell “atlas” of lung development in the mouse that tracks multiple cell types over time. ![]() Smith)ĭuring the last trimester of pregnancy, the developing lung is particularly vulnerable to being permanently damaged by increased oxygen exposure and inflammation that can result from an extremely premature birth. From left, Nicholas Negretti, PhD, Jonathan Kropski, MD, John Benjamin, MD, MPH, Jennifer Sucre, MD, and Erin Plosa, MD, led the research team that created a single-cell “atlas” of lung development. ![]()
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